Tlr4^tm1.1Jke
Targeted Allele Detail

Summary

• Symbol: Tlr4^tm1.1Jke
• Name: toll-like receptor 4; targeted mutation 1.1, Joel Elmquist
• MGI ID: MGI:6511933
• Synonyms: Tlr4^fl
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^tm1.1Jke page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253684
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 2, and a second loxP site followed by an FRT-flanked PGK-neo cassette just downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo. (J:253684)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 96 strains or lines available

References

• Original: J:253684 Jia L, et al., Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nat Commun. 2014 May 12;5:3878
• All: 8 reference(s)