Ryr2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm1.1Itl
• Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:6510234
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 8 was deleted via Cre-mediated recombination of flanking loxP sites. (J:302783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 330 strains or lines available

References

• Original: J:302783 Bertan F, et al., Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. Cell Death Differ. 2020 Dec;27(12):3354-3373
• All: 1 reference(s)