Rras^tm1.1Masak
Targeted Allele Detail

Summary

• Symbol: Rras^tm1.1Masak
• Name: RAS oncogene related; targeted mutation 1.1, Masanobu Komatsu
• MGI ID: MGI:6509163
• Synonyms: Rras^fl, Rras^tm2Itl
• Gene: Rras Location: Chr7:44667385-44671071 bp, + strand Genetic Position: Chr7, 29.08 cM
• Alliance: Rras^tm1.1Masak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334227
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site upstream of exon 2 and a second loxP site downstream of exon 6. An FRT-flanked neomycin selection cassette is inserted downstream of exon 6. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:334227)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rras Mutation: 22 strains or lines available

References

• Original: J:334227 Herrera JL, et al., R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development. J Vasc Res. 2021;58(4):252-266
• All: 2 reference(s)