Ace2^{tm1.1(ACE2)Mdk}
Targeted Allele Detail

Summary

• Symbol: Ace2^{tm1.1(ACE2)Mdk}
• Name: angiotensin converting enzyme 2; targeted mutation 1.1, Michael D Koob
• MGI ID: MGI:6509009
• Synonyms: ACE2-GR
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^{tm1.1(ACE2)Mdk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Ace2^{tm1.1(ACE2)Mdk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The targeting vector is designed to replace 71 kb (70,987bp) on the mouse X chromosome stretching from, but not including, collectrin, amino acid transport regulator (Cltrn) gene to BMX non-receptor tyrosine kinase (Bmx) gene with a syntenic 66 kb (65,812bp) region from the human X chromosome. A loxN-flanked neomycin resistance (neo) cassette was inserted at the junction between the human ACE2 and mouse Bmx genes. Transient cre-mediated recombination removed the floxed neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 72 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 4 reference(s)