Lyve1^{em1(Ncre)Jung}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lyve1^{em1(Ncre)Jung}
• Name: lymphatic vessel endothelial hyaluronan receptor 1; endonuclease-mediated mutation 1, Steffen Jung
• MGI ID: MGI:6508985
• Synonyms: Lyve1^ncre
• Gene: Lyve1 Location: Chr7:110449814-110462160 bp, - strand Genetic Position: Chr7, 57.89 cM, cytoband F2
• Alliance: Lyve1^{em1(Ncre)Jung} page

Mutation origin

• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Lyve1^{em1(Ncre)Jung} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lyve1 (MGI:2136348)

• Mutation details: CRISPR/Cas9 system inserted a cassette encoding a viral 2A oligopeptide (T2A) self-cleaving peptide, that mediates ribosomal skipping, fused to an N-terminal Cre recombinase fragment (NCre), directly downstream of the lymphatic vessel endothelial hyaluronan receptor 1 (Lyve1) gene. (J:302588)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyve1 (mouse) Summary of all recombinase alleles driven by Lyve1. Comparative matrix view of recombinase activities Alliance mouse Lyve1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyve1 Mutation: 15 strains or lines available

References

• Original: J:302588 Kim JS, et al., A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages. Immunity. 2021 Jan 12;54(1):176-190.e7
• All: 3 reference(s)