Gata3^tm1.1Hjf
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1.1Hjf
• Name: GATA binding protein 3; targeted mutation 1.1, Hans Joerg Fehling
• MGI ID: MGI:6508674
• Synonyms: GATIR
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1.1Hjf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288433
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A IRESvYFP reporter and a loxP flanked neomycin selection cassette was inserted into the 3-untranslated region of the endogenous gene. The neomycin selection cassette was removed via Cre-mediated recombination in the germline. Gata3 is expressed similarly to controls, and reporter expression mimics the endogenous expression of the gene. (J:288433)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 31 strains or lines available

References

• Original: J:288433 Rao TN, et al., Novel, Non-Gene-Destructive Knock-In Reporter Mice Refute the Concept of Monoallelic Gata3 Expression. J Immunol. 2020 May 1;204(9):2600-2611
• All: 2 reference(s)