Tril^tm1.1Kaf
Targeted Allele Detail

Summary

• Symbol: Tril^tm1.1Kaf
• Name: TLR4 interactor with leucine-rich repeats; targeted mutation 1.1, Katherine A Fitzgerald
• MGI ID: MGI:6508377
• Synonyms: Tril^-
• Gene: Tril Location: Chr6:53792453-53797810 bp, - strand Genetic Position: Chr6, 26.07 cM
• Alliance: Tril^tm1.1Kaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank the coding exon. The coding exon and neomycin selection cassette were deleted via Cre-mediated recombination in the germline. RT-PCR analysis of brain lysates confirmed the absence of mRNA expression in the brain of homozygous mutant mice while moderate to high expression was observed in heterozygous and wild-type mice, respectively. (J:301765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tril Mutation: 28 strains or lines available

References

• Original: J:301765 Wochal P, et al., TRIL is involved in cytokine production in the brain following Escherichia coli infection. J Immunol. 2014 Aug 15;193(4):1911-9
• All: 1 reference(s)