Mlkl^em1Soff
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em1Soff
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Stefan Offermanns
• MGI ID: MGI:6508108
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em1Soff page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an 8bp deletion, which was predicted to result in a knockout. (J:296726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:296726 Strilic B, et al., Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016 Aug 11;536(7615):215-8
• All: 3 reference(s)