Smox^tm1Sole
Targeted Allele Detail

Summary

• Symbol: Smox^tm1Sole
• Name: spermine oxidase; targeted mutation 1, Manoocher Soleimani
• MGI ID: MGI:6508089
• Synonyms: Smox-KO
• Gene: Smox Location: Chr2:131333624-131367103 bp, + strand Genetic Position: Chr2, 63.45 cM
• Alliance: Smox^tm1Sole page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296727
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced the genomic region containing exons 4-6. (J:296727)

Tumor Data

List all tumor models in MMHCdb carrying Smox^tm1Sole

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smox Mutation: 41 strains or lines available

References

• Original: J:296727 Zahedi K, et al., Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS One. 2017;12(9):e0184570
• All: 6 reference(s)