Cgas^tm1Ciphe
Targeted Allele Detail

Summary

• Symbol: Cgas^tm1Ciphe
• Name: cyclic GMP-AMP synthase; targeted mutation 1, Centre d'ImmunoPhenomique
• MGI ID: MGI:6508038
• Synonyms: Cgas^KI, Mb21d1^tm1Ciphe
• Gene: Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Cgas^tm1Ciphe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• An EGFP gene was inserted 5' to exon 1. (J:273171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cgas Mutation: 26 strains or lines available

References

• Original: J:273171 Gentili M, et al., The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus. Cell Rep. 2019 Feb 26;26(9):2377-2393.e13
• All: 1 reference(s)