Dsg2^tm2.2Leu
Targeted Allele Detail

Summary

• Symbol: Dsg2^tm2.2Leu
• Name: desmoglein 2; targeted mutation 2.2, Rudolf E Leube
• MGI ID: MGI:6508031
• Synonyms: Dsg2^mt
• Gene: Dsg2 Location: Chr18:20691247-20737583 bp, + strand Genetic Position: Chr18, 11.42 cM
• Alliance: Dsg2^tm2.2Leu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283222
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted in regions flanking exons 4-6. The neomycin selection cassette was removed via FLP-mediated recombination and exons 4-6 were deleted via Cre-mediated recombination in the germline . (J:283222)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsg2 Mutation: 81 strains or lines available

References

• Original: J:283222 Krusche CA, et al., Desmoglein 2 mutant mice develop cardiac fibrosis and dilation. Basic Res Cardiol. 2011 Jun;106(4):617-33
• All: 6 reference(s)