Csrp3^em1Yji
Endonuclease-mediated Allele Detail

Summary

• Symbol: Csrp3^em1Yji
• Name: cysteine and glycine-rich protein 3; endonuclease-mediated mutation 1, Yong Ji
• MGI ID: MGI:6507964
• Synonyms: MLP C79A
• Gene: Csrp3 Location: Chr7:48480146-48497781 bp, - strand Genetic Position: Chr7, 31.11 cM, cytoband B3
• Alliance: Csrp3^em1Yji page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a TGC to GCT change in exon 3 resulting in a cysteine to alanine substitution at amino acid 79 (C79A). (J:302253)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csrp3 Mutation: 15 strains or lines available

References

• Original: J:302253 Tang X, et al., SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)-Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation. Circulation. 2020 Mar 24;141(12):984-1000
• All: 1 reference(s)