Tg(Tek-EDN1)#Erls
Transgene Detail

Summary

• Symbol: Tg(Tek-EDN1)#Erls
• Name: transgene insertion, Ernesto L Schiffrin
• MGI ID: MGI:6507871
• Synonyms: h preproET-1 TG
• Transgene: Tg(Tek-EDN1)#Erls Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(Tek-EDN1)#Erls page

Transgene origin

• Strain of Origin: C3H x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tek-EDN1)#Erls expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EDN1 (1906)

  Edn1	(MGI:95283)

  Human cDNA, mouse promoter and enhancer

• Mutation details: The following elements comprise the transgene: mouse TEK receptor tyrosine kinase promoter, human endothelin 1 cDNA, mouse or rabbit beta-globin gene intron and poly(A) signal sequences, and Tek enhancer. Three transgenic mouse lines were established. (J:130618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130618 Amiri F, et al., Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation. 2004 Oct 12;110(15):2233-40
• All: 5 reference(s)