Sting1^em2Vnce
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em2Vnce
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 2, Russell E Vance
• MGI ID: MGI:6507862
• Synonyms: STING deltaCTT
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em2Vnce page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9-mediated genome editing is used to replace valine 340 with a premature stop codon in exon 8. The mutation disrupts the expression of the protein's C-terminal tail (CTT). Expression levels of the mutant protein are comparable to wild-type. (J:292197)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 45 strains or lines available

References

• Original: J:292197 Yamashiro LH, et al., Interferon-independent STING signaling promotes resistance to HSV-1 in vivo. Nat Commun. 2020 Jul 7;11(1):3382
• All: 1 reference(s)