Tg(PCSK9)4Prat
Transgene Detail

Summary

• Symbol: Tg(PCSK9)4Prat
• Name: transgene insertion 4, Annik Prat
• MGI ID: MGI:6507737
• Synonyms: Tg(RP11-55M23-AbsI)4Prat
• Transgene: Tg(PCSK9)4Prat Location: unknown
• Alliance: Tg(PCSK9)4Prat page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PCSK9)4Prat expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PCSK9 (255738)

  Pcsk9

  (MGI:2140260)

• Mutation details: The transgene consists of the human RP11-55M23 BAC, which includes the entire PCSK9 gene flanked with 35.5 kb and 7 kb of upstream and downstream DNA, respectively. Four founder lines were established, with line 4 having the highest expression. (J:302051)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:302051 Essalmani R, et al., A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice. Biol Chem. 2018;399(12):1363-1374
• All: 1 reference(s)