Tg(CAG-Aldh2*E487K)02Oht
Transgene Detail

Summary

• Symbol: Tg(CAG-Aldh2*E487K)02Oht
• Name: transgene insertion 02, Shigeo Ohta
• MGI ID: MGI:6507391
• Synonyms: Aldh2*2 Tg
• Transgene: Tg(CAG-Aldh2*E487K)02Oht Location: unknown
• Alliance: Tg(CAG-Aldh2*E487K)02Oht page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Aldh2*E487K)02Oht expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Aldh2 (MGI:99600)

• Mutation details: The transgene contains the mouse gene with the amino acid substitution of glutamic acid for lysine at position 487 (E487K) driven by the ubiquitously-expressing CAG promoter. This mutation is the same as in the human Aldh2*2 polymorphism, which acts as a dominant-negative gene. Line 02 was generated. (J:170150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:170150 Endo J, et al., Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res. 2009 Nov 20;105(11):1118-27
• All: 9 reference(s)