Sik3^tm2.1Iiis
Targeted Allele Detail

Summary

• Symbol: Sik3^tm2.1Iiis
• Name: SIK family kinase 3; targeted mutation 2.1, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:6506974
• Synonyms: Sik3^ex13flox, Sik3^Slpflox
• Gene: Sik3 Location: Chr9:45924118-46135492 bp, + strand Genetic Position: Chr9, 25.36 cM
• Alliance: Sik3^tm2.1Iiis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301630
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Exon 13 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:301630)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik3 Mutation: 71 strains or lines available

References

• Original: J:301630 Iwasaki K, et al., Induction of Mutant Sik3(Sleepy) Allele in Neurons in Late Infancy Increases Sleep Need. J Neurosci. 2021 Mar 24;41(12):2733-2746
• All: 3 reference(s)