Cadps^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Cadps^tm1Osb
• Name: Ca2+-dependent secretion activator; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6506969
• Gene: Cadps Location: Chr14:9646684-10097200 bp, + strand Genetic Position: Chr14, 6.37 cM, cytoband A2
• Alliance: Cadps^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241151
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting vector inserted a DT-A-pA/loxP/PGK-Neo-pA/loxP in intron 26, and an A to G nucleotide substitution in exon 27 that results in the amino acid substitution of glutamate with glycine at position 1252 (E1252G). (J:241151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadps Mutation: 70 strains or lines available

References

• Original: J:241151 Miyake K, et al., CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Rep. 2016 Nov 15;17(8):2004-2014
• All: 1 reference(s)