Kcnj3^tm2.1Kwn
Targeted Allele Detail

Summary

• Symbol: Kcnj3^tm2.1Kwn
• Name: potassium inwardly-rectifying channel, subfamily J, member 3; targeted mutation 2.1, Kevin D Wickman
• MGI ID: MGI:6506306
• Synonyms: Girk1^fl
• Gene: Kcnj3 Location: Chr2:55325982-55488157 bp, + strand Genetic Position: Chr2, 31.66 cM
• Alliance: Kcnj3^tm2.1Kwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263243
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites and an frt-flanked neomycin selection cassette. The selection cassette was removed via Flp-mediated recombination. (J:263243)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj3 Mutation: 33 strains or lines available

References

• Original: J:263243 Marron Fernandez de Velasco E, et al., Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core. Neuropharmacology. 2017 May 1;117:33-40
• All: 6 reference(s)