Wnt1^tm1.2Kiv
Targeted Allele Detail

Summary

• Symbol: Wnt1^tm1.2Kiv
• Name: wingless-type MMTV integration site family, member 1; targeted mutation 1.2, Riku Kiviranta
• MGI ID: MGI:6505570
• Synonyms: Wnt1^-
• Gene: Wnt1 Location: Chr15:98687738-98691711 bp, + strand Genetic Position: Chr15, 54.65 cM, cytoband F1-F3
• Alliance: Wnt1^tm1.2Kiv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284679
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Wnt1^tm1.1Kiv allele resulted in the exons 2-3 and disruption of exon 4 leaving behind the inserted single loxP sequence. (J:284679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt1 Mutation: 29 strains or lines available

References

• Original: J:284679 Wang F, et al., Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation. J Bone Miner Res. 2019 Jun;34(6):1129-1142
• All: 1 reference(s)