Arg2^tm1.1Frsv
Targeted Allele Detail

Summary

• Symbol: Arg2^tm1.1Frsv
• Name: arginase type II; targeted mutation1.1, Dmitri Firsov
• MGI ID: MGI:6505264
• Synonyms: Arg2^lox
• Gene: Arg2 Location: Chr12:79177562-79203075 bp, + strand Genetic Position: Chr12, 35.51 cM
• Alliance: Arg2^tm1.1Frsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300959
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance (neo) cassette, in reverse orientation to the gene, downstream of exon 6. A second loxP site is inserted downstream of the neo cassette. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 6 floxed. (J:300959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arg2 Mutation: 17 strains or lines available

References

• Original: J:300959 Ansermet C, et al., Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice. Acta Physiol (Oxf). 2020 Jul;229(3):e13457
• All: 3 reference(s)