Tnfrsf11b^em1Caob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfrsf11b^em1Caob
• Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); endonuclease-mediated mutation 1, Charles A O'Brien
• MGI ID: MGI:6504917
• Synonyms: Tnfrsf11b^f
• Gene: Tnfrsf11b Location: Chr15:54114014-54141700 bp, - strand Genetic Position: Chr15, 21.15 cM
• Alliance: Tnfrsf11b^em1Caob page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into introns 1 and 2 using an ssODN and sgRNAs with CRISPR/Cas9 technology. (J:300921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11b Mutation: 33 strains or lines available

References

• Original: J:300921 Cawley KM, et al., Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell Rep. 2020 Sep 8;32(10):108052
• All: 1 reference(s)