Ppp2r2b^tm1.1Strk
Targeted Allele Detail

Summary

• Symbol: Ppp2r2b^tm1.1Strk
• Name: protein phosphatase 2, regulatory subunit B, beta; targeted mutation 1.1, Stefan Strack
• MGI ID: MGI:6504904
• Synonyms: Bbeta2^-
• Gene: Ppp2r2b Location: Chr18:42777811-43192827 bp, - strand Genetic Position: Chr18, 22.75 cM, cytoband B3
• Alliance: Ppp2r2b^tm1.1Strk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290154
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The N-terminal 24 aa (exon 1) of Ppp2r2b have been replaced with the coding sequence for beta-gal (lacZ) and a neomycin cassette surrounded by two loxP sites followed by a polyadenylation signal to terminate the transcript. A correctly targeted mouse was crossed with a Cre deleter mouse to remove the neomycin cassette. The allele is a null allele. Loss of protain product was confirmed by Western blotting PP2A holoenzymes purified from total forebrain. (J:290154)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r2b Mutation: 37 strains or lines available

References

• Original: J:290154 Flippo KH, et al., Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. J Neurosci. 2020 Apr 8;40(15):3119-3129
• All: 1 reference(s)