Zrsr2^tm1.1Oaw
Targeted Allele Detail

Summary

• Symbol: Zrsr2^tm1.1Oaw
• Name: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2; targeted mutation 1.1, Omar Abdel-Wahab
• MGI ID: MGI:6504876
• Synonyms: Zrsr2^fl
• Gene: Zrsr2 Location: ChrX:162719268-162741662 bp, - strand Genetic Position: ChrX, 75.99 cM
• Alliance: Zrsr2^tm1.1Oaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320794
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector is designed to insert a loxP site upstream of exon 4 and a loxP- and an FRT-flanked neomycin resistance (neo) cassette, in reverse orientation to the gene, downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:320794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zrsr2 Mutation: 15 strains or lines available

Notes

ES cells are derived from C57BL/6 and carry a flp recombinase

References

• Original: J:320794 Inoue D, et al., Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 May;53(5):707-718
• All: 1 reference(s)