Dhx33^em1Yazh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dhx33^em1Yazh
• Name: DEAH-box helicase 33; endonuclease-mediated mutation 1, Yandong Zhang
• MGI ID: MGI:6502108
• Synonyms: DHX33^f, DHX33 lox
• Gene: Dhx33 Location: Chr11:70874917-70895258 bp, - strand Genetic Position: Chr11, 43.21 cM, cytoband B4
• Alliance: Dhx33^em1Yazh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology introduced two loxP sites flanking exons 2-4. Both loxP sites were inserted into nonconserved regions of intron 2-3 and intron 4-5 to minimize the possibility of disruption of gene expression. (J:299900)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhx33 Mutation: 22 strains or lines available

References

• Original: J:299900 Wang X, et al., Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo. Cancer Sci. 2020 Oct;111(10):3564-3575
• All: 2 reference(s)