Gt(ROSA)26Sor^{tm6(RET*,tdTomato)Cos}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm6(RET*,tdTomato)Cos}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Franklin Costantini
• MGI ID: MGI:6501786
• Synonyms: Rosa26-RetMEN2A-H2BTom
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm6(RET*,tdTomato)Cos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305439
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm6(RET*,tdTomato)Cos} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

  constitutively active

• Mutation details: The targeting vector was designed with, from 5' to 3', a floxed-STOP cassette that contains a neomycin cassette, a constitutively active mutant form of the mouse ret proto-oncogene cDNA, a viral T2A sequence, and a human histone H2B fused to a constitutively active red enhanced green fluorescence protein (tdTomato). The mutation in Ret is found in patients with multiple endocrine neoplasia type 2A. (J:305439)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 945 strains or lines available

References

• Original: J:305439 Packard A, et al., Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formation. Development. 2021 May 1;148(9):dev199386
• All: 1 reference(s)