Tg(CAG-GFP,-Prss2*)#Bji
Transgene Detail

Summary

• Symbol: Tg(CAG-GFP,-Prss2*)#Bji
• Name: transgene insertion, Baoan Ji
• MGI ID: MGI:6501771
• Synonyms: LGL-PACE trypsinogen
• Transgene: Tg(CAG-GFP,-Prss2*)#Bji Location: unknown
• Alliance: Tg(CAG-GFP,-Prss2*)#Bji page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The CAG promoter drives expresison of a floxed GFP and STOP cassette, and the paired basic amino acid-cleaving enzyme (PACE) rat Prss2 gene with a 5' signal peptide, trypsinogen activation peptide, and hemagglutinin tag. The original enteropeptidase cleavage site (DDDDK) was replaced by a PACE cleavage site (RTKR). (J:194451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194451 Gaiser S, et al., Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis. Gut. 2011 Oct;60(10):1379-88
• All: 2 reference(s)