Mmachc^em1Poche
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mmachc^em1Poche
• Name: methylmalonic aciduria cblC type, with homocystinuria; endonuclease-mediated mutation 1, Ross Poche
• MGI ID: MGI:6491439
• Synonyms: Mmachc^flox
• Gene: Mmachc Location: Chr4:116559631-116565582 bp, - strand Genetic Position: Chr4, 53.29 cM, cytoband C7
• Alliance: Mmachc^em1Poche page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR/Cas9 technology was used to insert loxP sites flanking exons 2 to 4. (J:297666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmachc Mutation: 30 strains or lines available

References

• Original: J:297666 Chern T, et al., Mouse models to study the pathophysiology of combined methylmalonic acidemia and homocystinuria, cblC type. Dev Biol. 2020 Dec 1;468(1-2):1-13
• All: 2 reference(s)