Klk1b5^em1Winu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klk1b5^em1Winu
• Name: kallikrein 1-related peptidase b5; endonuclease-mediated mutation 1, Wipawee Winuthayanon
• MGI ID: MGI:6488427
• Gene: Klk1b5 Location: Chr7:43865898-43870127 bp, + strand Genetic Position: Chr7, 28.73 cM, cytoband B2
• Alliance: Klk1b5^em1Winu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination created a 19 bp deletion in the 5' end of exon 2 resulting in a frameshift mutation. Quantitative RT-PCR analysis failed to detect expression in submandibular glands from homozygous mice. (J:290000)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klk1b5 Mutation: 10 strains or lines available

References

• Original: J:290000 Li S, et al., Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice. Mol Reprod Dev. 2019 Jun;86(6):611-613
• All: 1 reference(s)