Dazl^em1Huyc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dazl^em1Huyc
• Name: deleted in azoospermia-like; endonuclease-mediated mutation 1, Yueh-Chiang Hu
• MGI ID: MGI:6479898
• Synonyms: Dazl^{em1(tdTomato)Huyc}, Dazl-reporter
• Gene: Dazl Location: Chr17:50586422-50600627 bp, - strand Genetic Position: Chr17, 25.86 cM, cytoband B1
• Alliance: Dazl^em1Huyc page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 genome editing is used to insert a P2A-tdTomato sequence immediately 5' of the endogenous stop codon. (J:282807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dazl Mutation: 33 strains or lines available

References

• Original: J:282807 Nicholls PK, et al., Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25677-25687
• All: 2 reference(s)