Dazl^em1.1Dcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dazl^em1.1Dcp
• Name: deleted in azoospermia-like; endonuclease-mediated mutation 1.1, David C Page
• MGI ID: MGI:6479890
• Synonyms: Dazl-1L
• Gene: Dazl Location: Chr17:50586422-50600627 bp, - strand Genetic Position: Chr17, 25.86 cM, cytoband B1
• Alliance: Dazl^em1.1Dcp page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to introduce loxP sites to introns 3 and 7, flanking part of the RNA recognition motif (RRM) of the gene. Cre-mediated recombination removed exons 4 to 7. The mutation is predicted to result in a premature stop codon. (J:282807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dazl Mutation: 33 strains or lines available

References

• Original: J:282807 Nicholls PK, et al., Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25677-25687
• All: 3 reference(s)