Wdr45b^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Wdr45b^{tm1c(EUCOMM)Hmgu}
• Name: WD repeat domain 45B; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6479738
• Synonyms: Wipi3^flox
• Gene: Wdr45b Location: Chr11:121218050-121245271 bp, - strand Genetic Position: Chr11, 85.24 cM
• Alliance: Wdr45b^{tm1c(EUCOMM)Hmgu} page
• IMPC: Wdr45b gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298097
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt1 cassette was inserted at position 121229111 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin resistance gene sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 121229935. The critical exon(s) is/are thus flanked by loxP sites. This "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying the knockout allele. (J:298097)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr45b Mutation: 13 strains or lines available

References

• Original: J:298097 Yamaguchi H, et al., Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nat Commun. 2020 Oct 20;11(1):5311
• All: 1 reference(s)