Dip2b^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Dip2b^{tm1c(EUCOMM)Wtsi}
• Name: disco interacting protein 2 homolog B; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6478778
• Synonyms: DIP2B^loxP
• Gene: Dip2b Location: Chr15:99936545-100117354 bp, + strand Genetic Position: Chr15, 56.14 cM
• Alliance: Dip2b^{tm1c(EUCOMM)Wtsi} page
• IMPC: Dip2b gene page

Mutation origin

• Mutant Cell Line: EPD0113_2_D12
• Germline Transmission: Earliest citation of germline transmission: J:295176
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 100054583 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 100056131. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:295176)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dip2b Mutation: 138 strains or lines available

References

• Original: J:295176 Xing ZK, et al., DIP2B Interacts With alpha-Tubulin to Regulate Axon Outgrowth. Front Cell Neurosci. 2020;14:29
• All: 1 reference(s)