Nkx2-3tm1.1Rph
Targeted Allele Detail
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Symbol: |
Nkx2-3tm1.1Rph |
Name: |
NK2 homeobox 3; targeted mutation 1.1, Richard P Harvey |
MGI ID: |
MGI:6477947 |
Gene: |
Nkx2-3 Location: Chr19:43600764-43604331 bp, + strand Genetic Position: Chr19, 36.67 cM
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Alliance: |
Nkx2-3tm1.1Rph page
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was disrupted by the insertion of a construct containing IRES-NLS-lacZ followed by a floxed hygromycin selection cassette. The deleted region included nucleotides 2561 through 2860 (amino acids 149-251) encoding encoding the homeodomain and a conserved NK2-specific domain. Expression of beta-galactosidase was driven by the endogenous promoter. Cre-mediated recombination removed the selection cassette.
(J:64018)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nkx2-3 Mutation: |
14 strains or lines available
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Original: |
J:64018 Wang CC, et al., Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67 |
All: |
2 reference(s) |
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