Aff2^m1
Spontaneous Allele Detail

Summary

• Symbol: Aff2^m1
• Name: AF4/FMR2 family, member 2; mutation 1
• MGI ID: MGI:6477936
• Gene: Aff2 Location: ChrX:68403900-68911643 bp, + strand Genetic Position: ChrX, 35.53 cM, cytoband A5
• Alliance: Aff2^m1 page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: This allele represents five point mutations that are found in the PWD and PWK strains: chrX:g.69544913A>G (variant of SNP rs13483811; changes codon 229 from threonine to alanine (p.T229A)), 69830745C>T (major variant of SNP rs29044836; changes codon 432 from proline to serine (p.P432S)), 69830760C>G (minor variant of SNP rs29044835; changes codon 437 from proline to alanine (p.P437A)), 69830782A>T (minor variant of SNP rs29044834; changes codon 444 from glutamine to leucine (p.Q444L)) and 69834780G>A (novel SNP; changes codon 724 from serine to asparagine (p.S724N)) (GRCm38 coordinates). (J:292550)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aff2 Mutation: 16 strains or lines available

References

• Original: J:292550 Morimoto K, et al., Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis. Sci Rep. 2020 Jun 3;10(1):9060
• All: 1 reference(s)