Gt(ROSA)26Sor^{tm1(CAG-ECFP/Venus)Miur}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-ECFP/Venus)Miur}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Masayuki Miura
• MGI ID: MGI:6477357
• Synonyms: Rosa26-CAG-STOP-SCAT1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-ECFP/Venus)Miur} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297265
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A CAG-loxP-neo-loxP-SCAT1-pA cassette was inserted into the locus. SCAT1 is a sensor for caspase 1 activation based on FRET (ECFP/Venus). (J:297265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1058 strains or lines available

References

• Original: J:297265 Liu T, et al., Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response. Cell Rep. 2014 Aug 21;8(4):974-82
• All: 1 reference(s)