About   Help   FAQ
Gab2tm5.1Thir
Targeted Allele Detail
Summary
Symbol: Gab2tm5.1Thir
Name: growth factor receptor bound protein 2-associated protein 2; targeted mutation 5.1, Toshio Hirano
MGI ID: MGI:6477303
Gene: Gab2  Location: Chr7:96730958-96958158 bp, + strand  Genetic Position: Chr7, 53.39 cM, cytoband E2
Alliance: Gab2tm5.1Thir page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104881
Parent Cell Line:  M1/M-1 (ES Cell)
Strain of Origin:  (129 x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA cDNA encoding 89-665 amino acids was inserted into exon 2 of Gab2 gene. The cDNAs encoded Y441F/Y465F/Y573F/Y603F/Y632F mutant abolishing the SHP2 and PI3K-binding domains. Cre-mediated recombination removed the selection cassette. (J:104881)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gab2 Mutation:  37 strains or lines available
References
Original:  J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory