Gab2^tm5.1Thir
Targeted Allele Detail

Summary

• Symbol: Gab2^tm5.1Thir
• Name: growth factor receptor bound protein 2-associated protein 2; targeted mutation 5.1, Toshio Hirano
• MGI ID: MGI:6477303
• Gene: Gab2 Location: Chr7:96730958-96958158 bp, + strand Genetic Position: Chr7, 53.39 cM, cytoband E2
• Alliance: Gab2^tm5.1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104881
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A cDNA encoding 89-665 amino acids was inserted into exon 2 of Gab2 gene. The cDNAs encoded Y441F/Y465F/Y573F/Y603F/Y632F mutant abolishing the SHP2 and PI3K-binding domains. Cre-mediated recombination removed the selection cassette. (J:104881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gab2 Mutation: 37 strains or lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 2 reference(s)