Clec4a4^tm1.1Ksat
Targeted Allele Detail

Summary

• Symbol: Clec4a4^tm1.1Ksat
• Name: C-type lectin domain family 4, member a4; targeted mutation 1.1, Katsuaki Sato
• MGI ID: MGI:6477288
• Gene: Clec4a4 Location: Chr6:122967326-123001064 bp, + strand Genetic Position: Chr6, 58.07 cM
• Alliance: Clec4a4^tm1.1Ksat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236894
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: IRES-EGFP cassette was replaced with exon 1 and exon 2. Cre-mediated recombination removed the neomycin resistance cassette. (J:236894)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4a4 Mutation: 30 strains or lines available

References

• Original: J:236894 Uto T, et al., Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016 Apr 12;7:11273
• All: 2 reference(s)