Tsix^tm1.1Sado
Targeted Allele Detail

Summary

• Symbol: Tsix^tm1.1Sado
• Name: X (inactive)-specific transcript, opposite strand; targeted mutation 1.1, Takashi Sado
• MGI ID: MGI:6474212
• Synonyms: Tsix^deltaSA
• Gene: Tsix Location: ChrX:102475123-102528563 bp, + strand Genetic Position: ChrX, 46.13 cM
• Alliance: Tsix^tm1.1Sado page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297196
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The splicing acceptor site of exon 4 was replaced with a fragment containing an IRES-EGFP and a floxed puromycin resistance gene. This allele avoids the production major splicing variant. Cre-mediated recombination removed the selection cassette. (J:297196)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsix Mutation: 57 strains or lines available

References

• Original: J:297196 Sado T, et al., Tsix defective in splicing is competent to establish Xist silencing. Development. 2006;133(24):4925-31
• All: 1 reference(s)