Top2a^tm1Skmz
Targeted Allele Detail

Summary

• Symbol: Top2a^tm1Skmz
• Name: topoisomerase (DNA) II alpha; targeted mutation 1, Kazuhisa Sekimizu
• MGI ID: MGI:6473684
• Gene: Top2a Location: Chr11:98883769-98915015 bp, - strand Genetic Position: Chr11, 62.91 cM
• Alliance: Top2a^tm1Skmz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297171
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 9. (J:297171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Top2a Mutation: 92 strains or lines available

References

• Original: J:297171 Akimitsu N, et al., Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha. Genes Cells. 2003;8(4):393-402
• All: 1 reference(s)