Mbtd1^tm2Homy
Targeted Allele Detail

Summary

• Symbol: Mbtd1^tm2Homy
• Name: mbt domain containing 1; targeted mutation 2, Hiroaki Honda
• MGI ID: MGI:6473496
• Gene: Mbtd1 Location: Chr11:93776678-93837811 bp, + strand Genetic Position: Chr11, 58.86 cM
• Alliance: Mbtd1^tm2Homy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343210
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP was inserted upstream of exon 6 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Neo cassette was removed by crossing with FLPe mice. (J:343210)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mbtd1 Mutation: 85 strains or lines available

References

• Original: J:343210 Takubo K, et al., MBTD1 preserves adult hematopoietic stem cell pool size and function. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2206860120
• All: 1 reference(s)