Fbxw7^tm2.1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm2.1Kei
• Name: F-box and WD-40 domain protein 7; targeted mutation 2.1, Keiichi Nakayama
• MGI ID: MGI:6473304
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm2.1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297018
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Recombination removed the selection cassette and exon 1 beta. (J:297018)

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 81 strains or lines available

References

• Original: J:297018 Matsumoto A, et al., Fbxw7beta resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci. 2011;102(4):749-55
• All: 1 reference(s)