Eed^tm2.1Homy
Targeted Allele Detail

Summary

• Symbol: Eed^tm2.1Homy
• Name: embryonic ectoderm development; targeted mutation 2.1, Hiroaki Honda
• MGI ID: MGI:6473297
• Synonyms: Eed^{tm1(I363M)Homy}
• Gene: Eed Location: Chr7:89603862-89630184 bp, - strand Genetic Position: Chr7, 50.42 cM
• Alliance: Eed^tm2.1Homy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238281
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The allele contains the amino acid substitution of isoleucine with a methionine at position 363 (I363M). Cre-mediated recombination removed the selection cassette. (J:238281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eed Mutation: 117 strains or lines available

References

• Original: J:238281 Ueda T, et al., Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10370-5
• All: 1 reference(s)