Atp6v0c^tm1.1Ywd
Targeted Allele Detail

Summary

• Symbol: Atp6v0c^tm1.1Ywd
• Name: ATPase, H+ transporting, lysosomal V0 subunit C; targeted mutation 1.1, Yoh Wada
• MGI ID: MGI:6473167
• Gene: Atp6v0c Location: Chr17:24382839-24388652 bp, - strand Genetic Position: Chr17, 12.29 cM
• Alliance: Atp6v0c^tm1.1Ywd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312380
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exons 2 and 3. (J:312380)

Expression

In Mice Carrying this Mutation:

52 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp6v0c Mutation: 12 strains or lines available

References

• Original: J:312380 Sun-Wada GH, et al., Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm. Sci Rep. 2021 Sep 29;11(1):19355
• All: 1 reference(s)