Kiss1^tm1.1Nurep
Targeted Allele Detail

Summary

• Symbol: Kiss1^tm1.1Nurep
• Name: KiSS-1 metastasis-suppressor; targeted mutation 1.1, Lab. of Reproductive Science
• MGI ID: MGI:6472633
• Synonyms: Kiss1^fl
• Gene: Kiss1 Location: Chr1:133254950-133257460 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Kiss1^tm1.1Nurep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296176
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neomycin resistance cassette inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exon 3 floxed. (J:296176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kiss1 Mutation: 22 strains or lines available

References

• Original: J:296176 Ikegami K, et al., Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice. J Reprod Dev. 2020 Aug 20;66(4):359-367
• All: 1 reference(s)