Hcn4^tm1.1Nna
Targeted Allele Detail

Summary

• Symbol: Hcn4^tm1.1Nna
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1.1, Noriyuki Nakashima
• MGI ID: MGI:6471763
• Synonyms: Hcn4^{tm1.1(Luc/EGFP)Nna}, Hcn4^{tm1.1(Luc)Nna}
• Gene: Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
• Alliance: Hcn4^tm1.1Nna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296681
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A luciferase and GFP reporter allele was generated by insertion at the transcription start site. Cre-mediated recombination removed the loxP-flanked selection cassette. GFP fluorescence was too weak and indistinguishable from the autofluorescence signal. (J:296681)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn4 Mutation: 65 strains or lines available

References

• Original: J:296681 Kozasa Y, et al., HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node. J Physiol. 2018;596(5):809-825
• All: 1 reference(s)