Gt(ROSA)26Sor^{tm1(mVenus/Cdkn1b*)Toki}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(mVenus/Cdkn1b*)Toki}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Toshio Kitamura
• MGI ID: MGI:6471761
• Synonyms: B6.Cg-Gt(ROSA)26Sor^{tm1(mVenus/Cdkn1b<*})Toki>
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(mVenus/Cdkn1b*)Toki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300785
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the locus an adenovirus splicing acceptor, P1 phage LoxP sites, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neomycin resistant gene, HSV tk polyA, Aequorea victoria mVenus cDNA, mouse p27K-(mutant p27) gene cDNA, and SV40 virus PolyA signal. (J:300785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:300785 Fukushima T, et al., Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell Rep. 2019 Dec 17;29(12):4144-4158.e7
• All: 2 reference(s)