Chil3^{tm1(HBEGF)Mtka}
Targeted Allele Detail

Summary

• Symbol: Chil3^{tm1(HBEGF)Mtka}
• Name: chitinase-like 3; targeted mutation 1, Masato Tanaka
• MGI ID: MGI:6471755
• Synonyms: Ym1-DTR
• Gene: Chil3 Location: Chr3:106054870-106074852 bp, - strand Genetic Position: Chr3, 46.49 cM
• Alliance: Chil3^{tm1(HBEGF)Mtka} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296677
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Chil3^{tm1(HBEGF)Mtka} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hbegf (MGI:96070)

• Mutation details: Targeting introduced the human Diphtheria toxin receptor (DTR) into exon 1 at the transcription initiation site along with a FRT-flanked neomycin selection cassette. (J:296677)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chil3 Mutation: 53 strains or lines available

References

• Original: J:296677 Ikeda N, et al., Emergence of immunoregulatory Ym1+Ly6Chi monocytes during recovery phase of tissue injury. Sci Immunol. 2018;3(28):eaat0207
• All: 1 reference(s)