Aicda^tm1.1Evo
Targeted Allele Detail

Summary

• Symbol: Aicda^tm1.1Evo
• Name: activation-induced cytidine deaminase; targeted mutation 1.1, Kazuo Kinoshita
• MGI ID: MGI:6471730
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm1.1Evo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104881
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted two loxP sites flanking a segment of the gene and a tandem-dimer red fluorescent protein (tdRFP) reporter gene. Flp-mediated recombination removed the selection cassette. (J:347223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 57 strains or lines available

References

• Original: J:347223 Kinoshita K, et al., Stepwise generation of AID knock-in and conditional knockout mice from a single gene-targeting event. Int Immunol. 2021 Jun 18;33(7):387-398
• All: 2 reference(s)