Pparg^tm1.1Alsb
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Alsb
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Alexander S Banks
• MGI ID: MGI:6471170
• Synonyms: PPARgamma^A, PPARgamma^S273A
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Alsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: Site-directed mutagenesis was used to alter the codon for serine 273 to alanine (TCA to GCA) (p.S273A). This blocks phosphorylation of that residue in the encoded peptide. A loxP site flanked neomycin resistance gene cassette that was inserted into an intron, was removed through subsequent cre-mediated recombination. (J:296627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 42 strains or lines available

References

• Original: J:296627 Hall JA, et al., Obesity-Linked PPARgamma S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 Oct 6;32(4):665-675.e6
• All: 1 reference(s)